It has been studied the catalytic activity of synthetic (А, Х, Y) and natural (MOR, KlP) zeolites, modified by copper and palladium cations in the reaction of oxidative dehydrogenation of isobutyl alcohol to isobutyric aldehyde at different temperatures, space velocities and partial pressures of reagents. It has been determined that the bimetalzeolite catalyst of CuPdCaA containing weight %: 3.0 Cu²⁺ and 1.0 % Pd²⁺ shows high catalytic activity in this reaction