CHROMATOGRAPHIC METHOD OF SEPARATING ENANTIOMER OF A CHIRAL STRUCTURE OF THE RACEMIC MIXTURE
There has been carried out chromatographycal separation of S,S-enantiomer from racemic mixture, prepared by esterification of 6-methyl-15-hydroxy-1,4,7,10,13-pentaoxa-2,3,11,12-dibenzocyclohexadecane ether with L-alanine. R,S-izomer remains in cromatographic column bonded with starch. Separation is conditioned by the formation of strong hydrogen bond of amine group of S,S-izomer with crown еther ring. On the contrary, R,S-izomer is weakly linked with the crown ether ring and is heawily retained by adsorpbent
Keywords : racemik mixture, enantiomers, chiral structure, crown ethers, diastereomers
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