DETERMINATION OF ACID DISSOCIATION CONSTANTS OF SOME NEW 4-{[(5-(BROMO/CHLORO)-2-HYDROXYPHENYL)METHYLENE]AMINO}-5-ALKYL(ARYL)-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE DERIVATIVES AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY
Acid dissociation constants of some new 4-{[(5-bromo-2-hydroxyphenyl)methylene]amino}-5-alkyl(aryl)-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives were determined experimentally with potentiometric titration method and theoretically with SPARC computer program. The effect of solvents composition on the acid dissociation constants is discussed and experimental and theoretical values are compared. In the DPPH, free radical scavenging assay was achieved. The compounds have shown hydrogen-donating ability in the reaction with DPPH (1,1-diphenyl-2-picrylhydrazyl) radical.
Keywords : triazole, acid dissociation constants, antioxidant activity, potentiometric titration
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