The synthesis of a-naphthylacetic acids and aliphatic alcohol esters has been carried out. The optimal yield (80%) of the end products has been obtained in the presence of  nano-TiO₂ PC-500 at mole ratio of the acid to alcohol =
1:1.2, in the temperature range 80–90⁰C and reaction time 5–6 hours. Physico-chemical indices of the synthesized esters have been determined. The usage of the heterogeneous catalyst nano-TiO₂ allows to remove the intermediate stages of neutralization, washing and drying of raw esters and to increase the yield of esters of naphthylacetic acid and monoatomic alcohols yield by 10% in comparison with that of the industrial TiO₂.