Based on cyclohexanol, cyclic amines (piperidine, morpholine, hexamethyleneimine), and formaldehyde, new Mannich bases have been synthesized. The reaction was carried out at a temperature of 78–80⁰C for 4–5 h in a benzene solution at an equimolar ratio of the starting components. The yield of compounds was 69–75%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR, 1H and 13C NMR spectroscopy, and mass spectrometry. Their effect on the vital activity of sulfate-reducing bacteria of the "Desulfovibrio desulfuricans" type at three concentrations (25; 50; 100 mg/l) was studied. The obtained compounds showed high bactericidal properties, 1% solutions of these compounds in isopropyl alcohol at a concentration of 100 mg/l showed 100% bactericidal effect. A 1% solution of the compound with a fragment of morpholine already at a concentration of 50 mg/l exhibits a 100% bactericidal effect. Compounds with a fragment of piperidine and hexamethyleneimine at a concentration of 50 mg/l showed 96.2 and 98% bactericidal effects, respectively. And at a concentration of 25 mg/l, the bactericidal effect of all three compounds was 16.4%, 36.4%, and 58.2%, respectively. The results obtained show that the synthesized compounds showed more bactericidal properties compared to the industrially used bactericide-inhibitors АМДОР ИК-7 and АМДОР ИК-10 taken as a standard. Established, that these aminomethoxy derivatives of cyclohexanol affect bacteria at very low concentrations, they can be proposed as effective inhibitors against sulfate-reducing bacteria

doi.org/10.32737/0005-2531-2022-2-11-17