ISSN 0005-2531 (Print) ISSN 2522-1841 (Online)
NEW SYNTHESIS OF 3- AND 1,3-PYRAZOLE DERIVATIVES BASED ON 1-CYCLOALKYL-2,3-DICHLORO-1-PROPANONES
E.I.Mammadov, V.A.Huseynova, S.T.Mekhtieva, S.Q.Ismayilova

1-Cycloalkyl-2-propene-1-ones were synthesized by electrophilic addition of cycloalkanecarboxylic acid chlorides and its mono- and dichloride-substituted derivatives to ethylene in the presence of an AlCl3 catalyst at a temperature of –10 ÷ –150C in a dichloroethane medium. The resulting vinyl ketones were converted by chlorination in CCl4 at  –50C to the corresponding 1-cycloalkyl-2,3-dichloro-1-propanones, which form 1-R´-3-cycloalkylpyrazoles with hydrazine and phenylhydrazine in ethanol or toluene. The structure of the obtained pyrazoles was confirmed by the data of IR and H1NMR spectra and the determination of physical-chemical constants. Thus, preparative methods for the synthesis of 3- and 1,3-pyrazole derivatives have been developed for the first time

doi.org/10.32737/0005-2531-2022-4-89-94

 

Keywords : cycloalkanecarboxylic chlorides; 1-cycloalkyl-2-propene-1-ones; 1-cycloalkyl-2,3-dichloro-1-propanones; 3- and 1,3-substituted pyrazoles; electrophilic addition reaction; chlorination of vinylketones
View article
SUBMITION
THE LAST NUMBER OF THE JOURNAL
№3 2026
CONTENT
- STUDY OF THE PROCESS OF ELECTROREDUCTION OF ANTIMONY IONS FROM AN ACIDIC ELECTROLYTEN.A. Aliyeva Mammadova, S.F. Jafarova, S.P. Javadova, Sh.A. Ibrahimova, A.A. Aliyev, S.D. Dadashova, M.F. Nabiyeva, M.T.Abbasov, H.Ch. Aliyeva, D.B. Tagiyev
- WATERMELON RIND ADSORBENT FOR ATTENUATION OF HEAVY METAL CONTAMINATED WATER: GAUSSIAN PROCESS REGRESSION FOR RSM OPTIMIZATIONM. Abubakar, Y. A. Musti, I. U. Usman, W. C. Ulakpa, A. M. Abubakar, M. Al-HedrewyMore