Based on benzylthioctane-2-ol, heterocyclic amines (piperidine, morpholine, hexamethyleneimine), and formaldehyde, new Mannich bases were synthesized. The reaction was carried out at a temperature of 45–50⁰C for 3–4 h. in an equimolar ratio of starting compounds. The yield of target products was 70–74%. The physicochemical data of the synthesized compounds were determined. The composition and structure of the target products were confirmed by elemental analysis, IR and ¹H NMR spectroscopy. Their influence on the vital activity of sulfate-reducing bacteria of the Desulfovibrio desulfiricans type at three con­centrations (25, 50, 100 mg/l) was studied. The obtained compounds showed high bactericidal pro­perties, since 1% solutions of these compounds in isopropyl alcohol at a concentration of 100 mg/l showed a 100% bactericidal effect. Given that the aminomethoxy derivatives of 1-benzylthiooctane affect bacteria at very low concentrations, they can be proposed as effective inhibitors of sulfate reducing bacteria (SRB)

doi.org/ 10.32737/0005-2531-2023-4-31-39