There has been made a synthesis and carried out research of esters derived from natural synthetic petroleum and α-naphthyl acetic acids and methanol in the presence of nano-catalyst TiO2 (PC-500), 5–10 nm. An optimum yield (85.8%) of the end products were obtained at temperatures 79–800C, ratio acid:alcohol = 2:1.2, amount of catalyst 1.2 mas.% and reaction time in 14–15 hours. Composition, chemical structure and physical-chemical indices of synthesized esters were determined by IR-spectroscopic and analytic methods. It is shown that the usage of the heterogeneous nano-catalyst allows substantially to simplify the process of the esters obtaining due to removing intermediate stages, and to increase the esters yield by 10–20% in comparison with the process where the industrial TiO2 is used. It has been established that synthesized methyl esters reveal significant anti-oxidative effect and may be used as effective antioxidants for diesel fuels.