The interesterification reaction of the ethyl (I) and isopropyl (II) ethers of sulphoimides of saccharin-5- and -6-carboxylic acids with glycerine has been studied. The corresponding 2-hydroxypropyl-1,3-bis- esterosulphoimides of saccharin-5-and-6-carboxylic acids have been synthesized. They have been characterized by elemental analysis and method of the IR spectroscopy. It has been elucidated that in use of 10% PbO catalyst per mass of glycerine a yield of purposeful product reaches its greatest value –  82 and 85% depending on used saccharin: (-5-) or (-6-).