Catalytic properties of nano-grade titanium dioxide of mean size 5–10 nm have been studied in a model isopropylbenzene (cumene) oxidation. The kinetic data obtained indicate the significant catalytic activity of nano-TiO₂ for fairly broad concentration interval. The deep catalytic oxidation of cumene for 6 hours at 100⁰C affords mainly cumene hydroperoxide. The results can be used to prepare effective catalytic systems for oxidation of aromatic hydrocarbons