ISSN 0005-2531 (Print) ISSN 2522-1841 (Online)
SYNTHESIS OF GETARYLSULFAMIDES ON THE BASE OF ARYLSULFONYLHYDRAZIDES AND INVESTIGATION OF THEIR PROPERTIES
S.A.Mamedov, S.I.Mamedova, I.Sh.Guseynov, M.F.Farzaliyev, F.A.Kuliyev

 

It is established that at reaction of arylsulfonylhydrazides with 1,2-and 1,3-dipolarofiles getarylsulfamides with 65-80% yield form. It was found that monosulfonylhydrazides with acetyl acetone, benzoacetoaceticethyl ester and 4-oxymethylphenylmethylenemalonodinitrile form pirazolone-and pirazol derivatives of sulfamides. N-substituted derivatives of sulfanylhydrazide prepared by N-alkylation of sulfamide natrium by chloroacetonitrile is also sintone for obtaining of getarylsulfamides. This compound forms with benzoine-, pirazoline-, with acetyl acetone-, pyridazin-, but with acetoaceticethyl ester-, pyridazine derivatives of sulfamides. Investigations of antimikrobic properties of synthesized getarylsulfamides showed that 1-(4-methyl­phe­nylsulfonyl)-, 2-(4-aminopirazolines and 1-phenyl-3-(4-methylphenylsulfonyl)-pirazolone-3

Keywords : getarylsulfamides, arilsulfonylhydrazides, arylsulfochloride, dipolarofils, antimicrobial additives, acetyl­acetone
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№1 2024
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