Oxidation reactions of chloroalphatic hydrocarbons studied in the presence of vanadium based oxide catalysts at the temperature range 400–6000C. Showed that their reactivity increase by the growth of the amount of carbon atoms in the content and the order of catalytic activity have also been identified. Moerever, the oxidation of chlorinated C4 olefin hydrocarbons to maleic and chloro maleic anhydrides in the precense of V–P–O/Al2O3 and V–P–O/SiO2 has been studied. Possibility of forecasting the orientation of the oxidation reaction depending on the amount and position of chlorine atoms contained in olefins, and a double communication is shown. Selective oxidation directions and also the reactivity of chlorinated butadienes determinated. The effect of an initial oxidation reaction to the intermediate and final products’ oxidation reaction rate determined and explored that the main products of the reaction does not effect inhibiting to the reaction rate. The oxidation mechanism of chlorinated C4 hydrocarbons to maleic anhydride has been identified to occur by the passage intermediate chlorfuranone type compounds. The oxidation of clorbenzenes to maleic anhydride has to go parallel-sequential oxidation-reduction mechanism.