Tricomponental reaction of thiols with arylsulfamides and aminocompounds with formaldehyde and benzaldehyde has been studied. It was determined that the yield of sulfamide receiving in the result of reaction of ditiocarbamate and mercaptobenzthyozoles with benzaldehyde is low? It is evidently explained by steric factor. For being methylene group containing electronoacceptor sulfamide on the one hand, amine and sulfide group on the other hand in the structure of the synthesized substances these form pyrrol and pyrimidines joining to dipolarofyles very easily as dipolar compound. When some sulfamides which have been synthesized were examined as additive to greases it has determined that they show high effect anticorrosion and antiwear. And it has been found out that heterotcyclic derivates are highly effective bactericide. The derivates of streptocyd are more effective and its 4-aminosulfonil-2-N-izobutyl-5-methylpyrrolydon-3 derivates obliterates the microbe of staphylococc in the concentration of 0.05 %, stops the development of shtamms of typhoid fever.