The methyl reaction of arylsulphamides with alkylamine has been studied in the participation of paraform or benzaldehyde. As a catalyst NaOH has been used. It is established that with the increase in amount of alkali a yield of methylene sulphamide increases, whereas the products yield  when using benzaldehyde is lower than that with the participation of paraform. It is found that the amines in the 4-position is sulphamide aromatic area influence negatively on the yield of methylsulphamides because of the formation of functionally substituted pyrrols. The yield of substance with methylene derivatives of streptocide is less than with methylenebenzol- or -toluolsulphamides. The study of the bactericidal properties of the synthesized compounds showed that  the compounds containing the amines in 4-position in aromatic fragment more are effective than other derivatives. Among the derivatives of streptocid 1-(4-aminophe­nyl­sul­phonil-2-izobutilamino-3,5-dimethylpyrrol is more effective against staphylococcus and typhoid gever.