SYNTHESIS AND TRANSFORMATIONS OF 3-R-1-CARBAMOIL-5-CHLOROMETHYLPYRAZOLES
As a result of the reaction between 3,4-dichloro-2-butene-1-ones and semicarbazide hydrochloride with natrium hydrocarbonate, the hydrazones of ketones are produced. When boiled with the pyridine within surrounding of the dioxan, they are heterocyclized into 3-R-1-carbamoil-5-chloromethylpyrazoles. When the latter is influenced with binary amines and potassium phenolate, produced are 3-R-1-carbamoil-5-dialkylamino- and 3-R-1-carbamoil-5-phenoxymethylpyrazoles.
Keywords : semicarbazones of 3,4–dichloro-2-butene-1-ones, heterocyclization, 1-carbamoil-5-chlorinemethylpyrazoles, 1-carbamoil-5-dimethylamino(morpholino)methylpyrazoles, 1-carbamoil-5-phenoxymethylpyrazoles
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